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Year Number of Results
2005 1
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2014 4
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2021 6
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54 results

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The Eph receptor A4 plays a role in demyelination and depression-related behavior.
Li Y, Su P, Chen Y, Nie J, Yuan TF, Wong AH, Liu F. Li Y, et al. J Clin Invest. 2022 Apr 15;132(8):e152187. doi: 10.1172/JCI152187. J Clin Invest. 2022. PMID: 35271507 Free PMC article.
Pharmacological restoration of myelination normalized both synaptic deficits and depression-related behaviors. Furthermore, we found increased ephrin A4 receptor (EphA4) expression in the excitatory neurons of mice subjected to CUMS, and shRNA knockdown of EphA4 pre …
Pharmacological restoration of myelination normalized both synaptic deficits and depression-related behaviors. Furthermore, we found increas …
Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.
Lupiáñez DG, Kraft K, Heinrich V, Krawitz P, Brancati F, Klopocki E, Horn D, Kayserili H, Opitz JM, Laxova R, Santos-Simarro F, Gilbert-Dussardier B, Wittler L, Borschiwer M, Haas SA, Osterwalder M, Franke M, Timmermann B, Hecht J, Spielmann M, Visel A, Mundlos S. Lupiáñez DG, et al. Cell. 2015 May 21;161(5):1012-1025. doi: 10.1016/j.cell.2015.04.004. Epub 2015 May 7. Cell. 2015. PMID: 25959774 Free PMC article.
We show that distinct human limb malformations are caused by deletions, inversions, or duplications altering the structure of the TAD-spanning WNT6/IHH/EPHA4/PAX3 locus. Using CRISPR/Cas genome editing, we generated mice with corresponding rearrangements. Both in mouse lim …
We show that distinct human limb malformations are caused by deletions, inversions, or duplications altering the structure of the TAD-spanni …
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.
Van Hoecke A, Schoonaert L, Lemmens R, Timmers M, Staats KA, Laird AS, Peeters E, Philips T, Goris A, Dubois B, Andersen PM, Al-Chalabi A, Thijs V, Turnley AM, van Vught PW, Veldink JH, Hardiman O, Van Den Bosch L, Gonzalez-Perez P, Van Damme P, Brown RH Jr, van den Berg LH, Robberecht W. Van Hoecke A, et al. Nat Med. 2012 Sep;18(9):1418-22. doi: 10.1038/nm.2901. Nat Med. 2012. PMID: 22922411
Genetic as well as pharmacological inhibition of Epha4 signaling rescues the mutant SOD1 phenotype in zebrafish and increases survival in mouse and rat models of ALS. ...In humans with ALS, EPHA4 expression inversely correlates with disease onset and s …
Genetic as well as pharmacological inhibition of Epha4 signaling rescues the mutant SOD1 phenotype in zebrafish and increases surviva …
Genotype-phenotype correlation in clubfoot (talipes equinovarus).
Hordyjewska-Kowalczyk E, Nowosad K, Jamsheer A, Tylzanowski P. Hordyjewska-Kowalczyk E, et al. J Med Genet. 2022 Mar;59(3):209-219. doi: 10.1136/jmedgenet-2021-108040. Epub 2021 Nov 15. J Med Genet. 2022. PMID: 34782442 Review.
Last but not least, an equally important element, that brings us closer to a better understanding of the clubfoot genotype/phenotype correlation, are studies on the two known animal models of clubfoot-the pma or EphA4 mice. This review will summarise the curr …
Last but not least, an equally important element, that brings us closer to a better understanding of the clubfoot genotype/phenotype correla …
EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease.
Poppe L, Rué L, Timmers M, Lenaerts A, Storm A, Callaerts-Vegh Z, Courtand G, de Boer A, Smolders S, Van Damme P, Van Den Bosch L, D'Hooge R, De Strooper B, Robberecht W, Lemmens R. Poppe L, et al. Alzheimers Res Ther. 2019 Dec 12;11(1):102. doi: 10.1186/s13195-019-0554-4. Alzheimers Res Ther. 2019. PMID: 31831046 Free PMC article.
BACKGROUND: EphA4 is a receptor of the ephrin system regulating spine morphology and plasticity in the brain. ...These modifications were independent of hippocampal plaque load and beta-amyloid peptide levels since these were similar in mice with normal versus reduced leve …
BACKGROUND: EphA4 is a receptor of the ephrin system regulating spine morphology and plasticity in the brain. ...These modifications …
EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE).
Munro KM, Dixon KJ, Gresle MM, Jonas A, Kemper D, Doherty W, Fabri LJ, Owczarek CM, Pearse M, Boyd AW, Kilpatrick TJ, Butzkueven H, Turnley AM. Munro KM, et al. PLoS One. 2013;8(2):e55948. doi: 10.1371/journal.pone.0055948. Epub 2013 Feb 4. PLoS One. 2013. PMID: 23390555 Free PMC article.
Given that multiple sclerosis (MS) is primarily an inflammatory demyelinating disease and in mouse models of MS, such as experimental autoimmune encephalomyelitis (EAE), axonal degeneration and reactive gliosis are prominent clinical features, we hypothesised that e …
Given that multiple sclerosis (MS) is primarily an inflammatory demyelinating disease and in mouse models of MS, such as exper …
Blockade of Spinal EphA4 Reduces Chronic Inflammatory Pain in Mice.
Wang Y, Wen C, Xie G, Jiang L. Wang Y, et al. Neurol Res. 2021 Jul;43(7):528-534. doi: 10.1080/01616412.2021.1884798. Epub 2021 Feb 4. Neurol Res. 2021. PMID: 33541257
EphA4 receptor was blocked by intrathecal injection of EphA4-Fc, an EphA4 antagonist, and pain behaviors were measured by assessing thermal hyperalgesia and mechanical allodynia. ...Blocking spinal EphA4 receptor suppressed CFA-induced pain behaviors a …
EphA4 receptor was blocked by intrathecal injection of EphA4-Fc, an EphA4 antagonist, and pain behaviors were measured …
Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease.
Fu AK, Hung KW, Huang H, Gu S, Shen Y, Cheng EY, Ip FC, Huang X, Fu WY, Ip NY. Fu AK, et al. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64. doi: 10.1073/pnas.1405803111. Epub 2014 Jun 23. Proc Natl Acad Sci U S A. 2014. PMID: 24958880 Free PMC article.
The present study reveals an unanticipated role of erythropoietin-producing hepatocellular A4 (EphA4) in mediating hippocampal synaptic dysfunctions in AD and demonstrates that blockade of the ligand-binding domain of EphA4 reverses synaptic impairment in AD mouse …
The present study reveals an unanticipated role of erythropoietin-producing hepatocellular A4 (EphA4) in mediating hippocampal synapt …
Chromatin Remodeling in Patient-Derived Colorectal Cancer Models.
Xiang K, Wang E, Mantyh J, Rupprecht G, Negrete M, Sanati G, Hsu C, Randon P, Dohlman A, Kretzschmar K, Bose S, Giroux N, Ding S, Wang L, Balcazar JP, Huang Q, Sundaramoorthy P, Xi R, McCall SJ, Wang Z, Jiang C, Kang Y, Kopetz S, Crawford GE, Lipkin SM, Wang XF, Clevers H, Hsu D, Shen X. Xiang K, et al. Adv Sci (Weinh). 2024 Apr;11(16):e2303379. doi: 10.1002/advs.202303379. Epub 2024 Feb 21. Adv Sci (Weinh). 2024. PMID: 38380561 Free PMC article.
Patient-Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient-derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear. ...Among them, KLF14 and EG …
Patient-Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient-derived models of cancer (PDMC). Neve …
The identification of a novel isoform of EphA4 and ITS expression in SOD1(G93A) mice.
Zhao J, Boyd AW, Bartlett PF. Zhao J, et al. Neuroscience. 2017 Apr 7;347:11-21. doi: 10.1016/j.neuroscience.2017.01.038. Epub 2017 Jan 30. Neuroscience. 2017. PMID: 28153688
In transfected cells, both transcripts could be translated into proteins, which respectively contained the N- and C-termini of EphA4-FL, referred as EphA4-N and EphA4-C. EphA4-N, which was expressed on the surface of transfected cells, was shown to act …
In transfected cells, both transcripts could be translated into proteins, which respectively contained the N- and C-termini of EphA4- …
54 results